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Mouse Monoclonal Antibody to IKZF1
Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Mouse Monoclonal Antibody to IKZF1
Immunofluorescence analysis of Hela cells using IKZF1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Mouse Monoclonal Antibody to IKZF1
Flow cytometric analysis of Jurkat cells using IKZF1 mouse mAb (green) and negative control (red).
Mouse Monoclonal Antibody to IKZF1
Mouse Monoclonal Antibody to IKZF1
Mouse Monoclonal Antibody to IKZF1

Mouse Monoclonal Antibody to IKZF1

  • 货号:

    32119
  • 别名:

    IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452
  • 产品上架时间:

    2024-01-01
  • 应用:

    IF,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q13422
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to IKZF1

Description

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

References

1,Observational Study Medicine (Baltimore). 2020 Oct 9;99(41):e22607.
2,J Pediatr Hematol Oncol. 2020 Oct;42(7):420-428.

Specification

Aliases IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452
Entrez GeneID 10320
Swissprot Q13422
clone 1C1B6
WB Predicted band size 57.5kDa
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human IKZF1 (AA: 401-520) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IF/ICC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
XML 地图