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Rabbit Polyclonal Antibody to CYFIP2
-
货号:
P01247 -
别名:
PIR121 -
应用:
WB,IHC -
反应种属:
Human, Mouse -
抗体类型:
Primary antibody -
Swissprot:
Q96F07 -
规格:
-
数量:
-+ -
说明书:
目录价¥1980

Rabbit Polyclonal Antibody to CYFIP2
Description |
---|
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation. |
Specification |
|
---|---|
Aliases | PIR121 |
Swissprot | Q96F07 |
WB Predicted band size | 148 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Fusion protein of human CYFIP2 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
---|---|
WB | 1/500-1/2000 |
IHC | 1/50-1/200 |
ELISA | 1/2000-1/5000 |
Product Image
- Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, human fetal brain tissue, Primary antibody: P01247(CYFIP2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
- The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P01247(CYFIP2 Antibody) at dilution 1/25. (Original magnification: ×200)
- The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P01247(CYFIP2 Antibody) at dilution 1/25. (Original magnification: ×200)
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#P01247

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