Description
Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.Tissue specificity: Highly expressed in testis and at lower levels in the submandibular salivary gland.

References
1. Exp Cell Res. 2004 Oct 15;300(1):72-83. 2. Gene. 1994 Jan 28;138(1-2):171-4.

Specification
Aliases	DKIR; C3IP1; FLJ27152; KLHL12
Entrez GeneID	59349
Swissprot	Q53G59
clone	2G2
WB Predicted band size	63kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human KLHL12 expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500 - 1/2000
ELISA	1/10000